Acid tolerance mechanisms utilized byStreptococcus mutans
نویسندگان
چکیده
منابع مشابه
Acid tolerance of biofilm cells of Streptococcus mutans.
Streptococcus mutans, a member of the dental plaque community, has been shown to be involved in the carious process. Cells of S. mutans induce an acid tolerance response (ATR) when exposed to sublethal pH values that enhances their survival at a lower pH. Mature biofilm cells are more resistant to acid stress than planktonic cells. We were interested in studying the acid tolerance and ATR-induc...
متن کاملProteome analysis of Streptococcus mutans metabolic phenotype during acid tolerance.
Two-dimensional gel electrophoretic analysis of the proteome of Streptococcus mutans grown at a steady state in a glucose-limited anaerobic continuous culture revealed a number of proteins that were differentially expressed when the growth pH was lowered from pH 7.0 to pH 5.0. Changes in the expression of metabolic proteins were generally limited to three biochemical pathways: glycolysis, alter...
متن کاملAcid Stress Survival Mechanisms of the Cariogenic Bacterium Streptococcus mutans
Streptococcus mutans, the major etiological agent in human dental caries, is capable of forming a biofilm, or dental plaque, on the tooth surface (Loesche, 1986; Tanzer et al., 2001). S. mutans generates large amounts of acid within dental plaque from fermentable dietary carbohydrates. During meals, the ingestion of carbohydrates causes the pH of the dental plaque to fall below 4.0. Acid accumu...
متن کاملCharacterization of a glutamate transporter operon, glnQHMP, in Streptococcus mutans and its role in acid tolerance.
Glutamate contributes to the acid tolerance response (ATR) of many Gram-negative and Gram-positive bacteria, but its role in the ATR of the oral bacterium Streptococcus mutans is unknown. This study describes the discovery and characterization of a glutamate transporter operon designated glnQHMP (Smu.1519 to Smu.1522) and investigates its potential role in acid tolerance. Deletion of glnQHMP re...
متن کاملChitosan nanoparticles affect the acid tolerance response in adhered cells of Streptococcus mutans.
In this study we evaluated the effect of chitosan nanoparticles on the acid tolerance response (ATR) of adhered Streptococcus mutans. An ATR was induced by exposing S. mutans to pH 5.5 for 2 h and confirmed by exposing the acid-adapted cells to pH 3.5 for 30 min, with the majority of cells appearing viable according to the LIVE/DEAD® technique. However, when chitosan nanoparticles were present ...
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ژورنال
عنوان ژورنال: Future Microbiology
سال: 2010
ISSN: 1746-0913,1746-0921
DOI: 10.2217/fmb.09.129